Nicholas Spanos was born in Greece, where he took his first singing lessons at the age of 21 with Helen Lionna and Aris Christofellis. In 2000 he continued his studies in the Graduate Department of the University of Maryland School of Music in the U.S.A. with soprano Linda Mabbs (voice) and Leon Major (stage director). For his studies he held a scholarship from the "Friends of Music Society" in Athens, as well as an assistantship from the University. He graduated in 2002 with a Master's Degree in Voice/Opera Performance. He has diplomas in Harmony (1997) and Counterpoint (1999) from the New Conservatory of Thessalonica (class of N. Solomonides). He has actively participated in numerous voice masterclasses taught by prominent teachers, such as Kurt Equiluz, Delores Ziegler, Anna Tomowa - Sintow and Michael Chance. In 2007 and 2008 he gave masterclasses in Baroque style and singing technique in Ayios Lavrendios, Greece, in the Music Village Seminar. In 2006 he founded the "Trissevjeni Kalokyri Vocal Ensemble" in Thessalonica, Greece and has been conducting it since.

Nicholas Spanos has been acclaimed for his excellence in opera performance, as well as oratorio and recital. Kiriakatiki Avyi regarded him as “the big revelation” and has praised his singing as “melodic and soft, yet colored with passion”. Eleftherotypia found that he sings with “touching tenderness and exemplary musicality, featuring versatile melodic phrasing, pursued and accomplished with perfectionism”, while Estia describes his skill as one of “impressive, impeccable technique and expressive clarity” and praises his “originality and high level of his appearance”. Kathimerini called him a “rising star” whereas Vima cited his name as “a name to be read, written, learned and remembered”. International press mentions his “surprisingly potent voice for a countertenor” (Opèra International) as well as his “sweet timbre, beautiful legato and flair for ornamentation that go along with credible acting” (L’opera). Der Neue Merker finds his voice “tender and full of expression”, whereas Giornale della musica praises “his sweet, yet strong timbre” and finds that “his musical intelligence offers him good control over the technical capabilities”. The Washington Post called him “an extraordinary countertenor”.

Nicholas Spanos has preformed in Greece as well as in the United States. He has collaborated with modern Greek and foreign composers such as G. Kouroupos, D. Kamarotos, C. Selamsis, D. Soldier, as well as many orchestras, namely The Athens State Orchestra, The Thessaloniki State Orchestra, The Orchestra of Colours, Radio Symphony Orchestra of Denmark, Camerata Stuttgart, Bach Sinfonia. He also sings occasionally with early music ensembles, such as “Ex Silentio” and “Latinitas Nostra”.

He sang the part of Vladimir Lenin in Dave Soldier’s opera “Naked Revolution”, staged by the Multimedia Department of George Mason University, in Virginia. Also, he has created the role of Ludwig Schumann in the semi-staged world premiere of Robert Convery’s “Clara Schumann” at the Clarice Smith Performing Arts Center in Maryland, obtaining favourable reviews. A “wonderful, passionate and masculine Arsamene”, he sang in the Greek National Opera production of G. F. Händel’s “Serse” in Athens. His Nerone in Monteverdi’s “L’incoronazione di Poppea” (Clarice Smith Performing Arts Center, MD, U.S.A.) was highly acclaimed by the “Washington Post”. In October 2002 he sang the part of Der Hüter der Schwelle in Richard Strauss’ “Die Frau ohne Schatten” in the Athens Megaron Concert Hall (cast including Inga Nielsen and Eva Màrton, stage director Michael Hampe) with The Radio Symphony Orchestra of Denmark under the baton of Michael Schønwandt. After that came Ruggiero in Vivaldi’s “Orlando Furioso” in the National Opera, in January 2003, and Filotete in Händel’s “Oreste” in July 2003. Later, in 2004, Prince Go-Go in Ligeti’s “Le Grand Macabre” in the National Opera of Greece and after that, Prince Orlofsky in Johann Strauss’ “Die Fledermaus”. In 2006 he was Tamerlano in the Athens Festival's production of Händel's opera, whereas in October 2007 he sang The Page in R. Strauss' "Salome". For all the aforementioned roles Mr. Spanos has been mentioned to very favourably in both the Greek and international Press. In November 2002 he was awarded the Best Young Artist of the Year Award for his interpretation of Arsamene in Händel’s “Serse”.

He has recorded 2 Händel operas ("Oreste" and "Tamerlano") with the german label MDG. "Tamerlano", in which Spanos holds the title role, was awarded the 2008 "ECHO KLASSIK" as "Operneinspielung des Jahres".

His repertory ranges from early Baroque opera parts, such as Nerone (Cl. Monteverdi, L' incoronazione di Poppea) and Orfeo (Gluck, Orfeo ed Euridice), into contemporary parts composed for the countertenor voice, such as Oberon (Britten, Midsummer night’s dream).